10 Warning Signs Your Kidneys May Be in Danger, 1. Changes in Urination 2. Fatigue and Weakness 3. Swelling (Edema) 4. Persistent Back Pain 5. Unexplained Weight Loss or Loss of Appetite 6. Nausea and Vomiting 7. Difficulty Sleeping 8. Metallic Taste in the Mouth 9. Muscle Cramps and Twitching 10. Itchy Skin, The accumulation of toxins due to reduced kidney function can lead to intense, generalized itching
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